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Consistent with this hypothesis, interrogation of our gene expression microarray data sets revealed increased expression of several JNK regulatory genes including the toxicity and JNK inducer TAJ ( TNFRSF19 , 8.33-fold, adjusted P -value 1.25 10 18 , Supplementary Table 1), and JNK target genes including the p53-inducible proteins TP53I3 ( PIG3 , 5.02-fold, adjusted P -value 1.73 10 16 ) and CDKN1A ( p21 , 4.87-fold, adjusted P -value 9.62 10 15 ) in GSTP1 knockdown cells

doi: 10.1016/j.ajpath.2012.09.016 194 LeeFTCaoZLongDMPanagiotopoulosSJerumsGCooperMEet al

Mice engineered to express only C/EBP- LAP ( Cebp uORF ) show a marked reduction of age-related impairment and increased lifespan in female animals ( Cebp uORF animals

in about 20% of dissected germlines, MPK-1 protein was detected in the distal mitotic region (unpublished data)