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Chronic stress is considered a key precipitating factor in central nervous system dysfunction in ME/CFS and may impair brain structure and function through multiple mechanisms

examined 41 tissue samples (including 9 papillary thyroid cancer tissues) (97) and found that their Se levels and GPx activity were lower than those of non-cancerous tissues, while malondialdehyde (MDA) concentrations were increased

Other participants in the TCA cycle are also more active in KRAS-mutant tumors, particularly in pancreatic ductal adenocarcinoma (PDAC), where the increased expression of GOT1/2 supports glutamine metabolism while producing NADPH to maintain REDOX balance [50]