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Description

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Reduction of trioses by NADPH-dependent aldo-keto reductases

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From the docking analysis, the GTs active site can accommodate epothilone properly to facilitate the conjugation via the thiol-epoxide reaction with a binding affinity 8.0 kcal/mol, revealing the favorable interaction with the enzyme binding pocket to form glutathione-epothilone conjugate (12-hydroxy-13-(glutathion-S-yl) Epothilone B)

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