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Heme oxygenase-1 (HMOX1) is a key regulatory gene of ferroptosis in atherosclerosis (67)

CNS central nervous system Receptor-mediated targeting may further be combined with non-specific drug delivery systems (like protein conjugates, PEGylation, nanoparticles, liposomes, and the like) to greatly improve the pharmacokinetic and bio distribution properties of the drugs, which will significantly redirect the drugs specifically to receptor-expressing cells, tissues and organs, including the ones protected by specific blood-tissue barriers like e.g., the CNS, the blood-brain barrier (BBB), the retina and the testes

however, several ancestry-specific signals were markedly attenuated when combining populations, likely reflecting heterogeneity in allele frequencies and LD patterns