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This notion is in agreement with the hypothesis that albumin facilitates transport of amphiphilic ligands across cell membranes involving interactions of ligandprotein complexes with the membrane surface and transfer of the ligand into the membrane by lateral diffusion[68]

In contrast, molecule 3 (P-617769798) showed a higher IC 50 value, and molecules 1 (P-14421887) and 2 (P-25746649) yielded inconsistent results, likely due to solubility issues in the experimental setup

In the case of the PLV, we first applied a Kruskal-Wallis test and further a non-parametric permutation test with 1000 permutations to each of the significantly different PLVs to correct for multiple comparisons across the full range of functional connectivity pairings