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Addressing these knowledge gaps through genotype-stratified trials, the inclusion of advanced disease and co-infected cohorts, and transparent TRL mapping will be key to transitioning from promising proof-of-concept to clinically adoptable and affordable therapies [209,210,211]

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Aptamers-short, single-stranded oligonucleotides selected through systematic evolution of ligands by exponential enrichment (SELEX)-offer a powerful, flexible, and stable targeting modality ( We hypothesized that a fibrin-targeted, ROS-responsive GO nanocomposite encapsulating GSH (GO@GSH-FA) would selectively accumulate in ischemic brain regions and release its antioxidant payload in response to local oxidative stress