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Synthesis of the cryogel For the cryogel preparation, a specific ratio of Kr (0.3 g) and Gel (0.03 g) was mixed in distilled water (D.W.), then NaOH (0.5 M) was added dropwise to achieve a final pH of 8.0 0.2, as measured by a calibrated pH meter

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It can be induced to undergo endoplasmic reticulum stress in response to inflammation, oxidative stress, and hypoxia, thereby regulating intracellular environmental homeostasis through unfolded protein responses