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Changes in cholesterol levels were also observed in another study using iPSC-derived astrocytes harboring the Swedish mutation in the amyloid precursor protein (APP) gene (117)

It is known that motor neurons are particularly susceptible to free radicals generated during ischemia, and therefore chronic deficits in neural perfusion may contribute to the development of neuronal damage and disease progression (Kalaria 2002

While NAC is commonly used topically in human ophthalmology to treat corneal wounds, chemical injuries, keratitis, dry eye disease, and meibomian gland dysfunction, studies investigating the effect of NAC on pathogenic bacterial strains causing corneal ulceration in dogs and cats are lacking [136,153]