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Risks and side effects While most muscle-building supplements are safe when used properly, potential issues include: Digestive upset from low-quality protein powders Water retention from creatine (temporary and intracellular) Interactions with medications (especially magnesium or vitamin D at high doses) Contamination risks from unverified supplement brands Choosing third-party-tested, high-quality supplements reduces risk significantly

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Data on pediatric SN-AIH, although limited, have reported a wide range of prevalence (mean 19%, range 029%) [4, 5, 9, 15, 18, 30, 31, 177,178,179,180]