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Firstly, in 2008, Varma et al (123) evaluated the effect of caffeine on cultured and UV radiation-exposed mice lenses and revealed that caffeine significantly maintained the active transport activity, GSH levels and transparency of lenses

However, further research is needed to characterize the cellular and molecular processes involving APOE4 that may exacerbate alpha-synuclein pathology (Davis et al., 2020)

Therefore, the effects of obestatin on pituitary hormone secretions remain controversial

This comprehensive approach underscores the importance of considering genetic, molecular, and biomechanical factors in developing strategies to protect and enhance the health of the ACL and overall joint function