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PDX GBM models Animal studies were performed in accordance with the German Animal Welfare Act and approved by local authorities (Landesamt fr Gesundheit und Soziales, LaGeSo Berlin, Germany) under the permission H0308/18 for the PDX generation and proliferation in vivo and A0010/19 for in vivo therapy experiments

Acknowledgements This work was financially supported through grants from the Guangdong Basic and Applied Basic Research Foundation (2019B1515120043), National Natural Science Foundation of China (File No