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Some research suggests that feverfew may help prevent migraine headaches, but results have been mixed

Phytomedicine 57, 255261

Furthermore, this process has been shown to inhibit translocation of DAMPs, such as high mobility group box 1, thereby attenuating NF-B signaling in macrophages

Its use has been discontinued in many countries because of its antinutrient properties, decreasing the absorption of various dietary metals (e.g., phosphorus, zinc, calcium, and copper) in the gastrointestinal tract (Bloot et al., 2023)