The method according to any one of claims 7 to 11, characterized in that the calcium salt of N 5 , N 1o- methylene-5,6,7,8-tetrahydrofolic acid is prepared by reaction at room temperature of 5,6,7,8- Tetrahydrofolic acid in water with a compound selected from the group consisting of alkali metal hydroxides, alkali metal carbonates, alkali metal bicarbonates, ammonia and organic bases containing nitrogen, such as pyridine, triethylamine, triethanolamine, then a water-soluble, aromatic, nitrogen-containing base to this salt solution thus prepared adds which is selected in particular from the group consisting of pyridine and substituted pyridines, for example picolines, lutidines, ethylpyridines, pyridine being preferred, then reacting the salt solution thus prepared with formaldehyde, and then adding an aqueous solution of a calcium salt, where the calcium salt of N 5 , N 1 -methylene-5,6,7,8-tetrahydrofolic acid re fails
Copper peptides help through improved skin quality and some collagen building but typically produce softening rather than elimination of established nasolabial folds
The copper-bound peptide, Glycyl-L-Histidyl-L-Lysine-Copper(II) (GHK-Cu), is a naturally occurring complex ubiquitous in human biological fluids such as plasma, saliva, and urine
doi: 10.7150/jca.37335 179 WangYXieJWangHHuangHXieP
