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3.1 Maintaining the integrity of intestinal epithelial cells: anti-oxidation and anti-inflammation 3.1.1 Reactive oxygen species and Intestinal inflammation Intestinal inflammation can influence the intestinal-liver axis, damaging the intestinal barrier, leading to bacterial translocation, activating the immune system response, and triggering a series of pro-inflammatory pathways in the liver, thereby accelerating the process of NAFLD (Pierantonelli and Svegliati-Baroni, 2019)

Additionally, the formation of abundant heterointerfaces within the composite accelerated ionic diffusion and improved electron transport, significantly boosting electrochemical performance

Therefore, SIRT6 plays a key role in regulating glucose and lipid metabolism and signaling, particularly in DKD (Wang et al., 2023c)