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The cellular production of hydrogen peroxide

In oxidative stressoriented in vitro models, such as primary porcine theca cells, a broader doseresponse evaluation revealed that EV treatment (30120 g/mL for 24 h) reduced reactive oxygen species accumulation, limited apoptosis, and enhanced steroidogenic activity, underscoring the importance of aligning EV dose and duration with the specific stress paradigm and cellular target (Yuan et al., 2022)

Anti-inflammatory, antioxidant and neuroprotective effects Sub-chronic administration was evaluated in four studies, where single erinacine compounds or HEME were administered daily for five to 7 days by intraperitoneal injection or oral gavage ( Multiple studies used rodent model systems to elucidate the therapeutic potential of erinacines in neurodegeneration (n = 5)

The combination treatment group exhibited significantly reduced levels of intratumoral cysteine (Fig