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The ER was implicated as a site for virus replication complex (VRC) formation through co-localization of an ER marker, BiP, with MP-GFP and in turn, MP-GFP co-localization with replication proteins during immunofluorescence studies (Heinlein et al., 1998)

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Cannabis use exhibits a similarly paradoxical profile: acutely, some individuals report anxiolytic or mood-elevating effects from cannabis, yet sustained use is associated with worsened symptom severity, poorer treatment adherence and poorer functional outcomes 39

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