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The significantly higher numbers of peripheral RGCs in the KD + OHT group versus Control are consistent with our previous study that showed the neuroprotective effect of the ketogenic diet in the DBA/2 J model of glaucoma (Harun-Or-Rashid et al., 2018)

A decrease in NAD+ adversely impacts cellular energy metabolism, while a reduction in SAM hinders the activation of genes that are vital for boosting metabolism