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Maternal use of ACE inhibitors crosses the placenta, leading to fetal hypotension and decreased renal perfusion

In vitro studies demonstrated that hesperetin, the aglycone of hesperidin, stimulated the phosphorylation of key proteins (Src, Akt, AMP kinase (AMPK), and eNOS) in bovine aortic endothelial cells, leading to enhanced NO production

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