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Description

The development of antioxidant drugs that directly bind ROS may be a dead end since their effectiveness is much lower in comparison with those targeting the cellular antioxidant system

As it was mentioned in the previous section, the shift of the balance from OXPHOS towards glycolysis leads to a reduction of ROS accumulation [3, 103] (Figure 3)

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Jiang VC, Hao D, Jain P, Li Y, Cai Q, Yao Y, Nie L, Liu Y, Jin J, Wang W, Lee HH, Che Y, Dai E, Han G, Wang R, Rai K, Futreal A, Flowers C, Wang L, Wang M