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Researchers theorize that asthma may be due to either inappropriate mast cell activation or that the mast cells are hypersecretory.[ref][ref] One study sums up that mast cells release preformed mediators including chymase, tryptase, and histamine and de novo synthesized mediators such as PGD2, LTC4, and LTE4 in addition of cytokines mainly TGF1, TSLP, IL-33, IL-4, and IL-13 participate in the pathogenesis of asthma.[ref] Related article : Asthma: understanding the genetics and underlying causes Osteoarthritis: Mast cells as a causative factor Osteoarthritis, the most common form of arthritis, is caused by inflammation and degeneration of the joint tissue

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24, 39, 40, 268, 269 A key issue for future clinical trial design will be to identify clinically relevant objective criteria for patient enrollment, and this remains a challenge, which has delayed a more aggressive approach of the pharmaceutical industry to identifying new treatment avenues for this condition

MOPS, 3-(N-morpholino) propanesulfonic acid