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Description

A suggested approach for future application of this methodology would be to characterize specific abnormalities in iPSC-derived DA neurons from subjects with prevalent or persistent NS, and use them to test novel pharmacologic agents/AP aimed to revert these changes in vitro

These morphological alterations completely mirror decreased function in dorsomedial PFC and dorsolateral PFC and provide strong support for the hypothetical impairment of neuroplasticity in bipolar disorder (144)