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Indeed, while immune dysfunction is evident across all stages of psychosis-spectrum disorders [54], an exacerbated inflammatory cascade characterized by elevated proinflammatory cytokine production has been found as independent of antipsychotic medication and present in both first episode (IL-12, IFN-, TNF-, and sIL-2R) and acutely relapsed phase (IL-1, IL-6, and TGF-) of psychotic patients [55], while a recent meta-analysis has reported that proinflammatory cytokines (mainly IFN-, IL-6 and IL-12) are significantly elevated in drug nave FEP populations and associated with presenting negative symptomatology [56]

Additionally, research is increasingly emphasizing personalized approaches, aiming to tailor treatments to individual patient profiles

A cutting-edge immunomodulatory interlinkage between HOTAIR and MALAT1 in tumor-associated macrophages in breast cancer: a personalized immunotherapeutic approach