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The presence of platelets in the spleen due to cancer or severe liver diseases, leukemia, certain types of anemia, viral infections, exposure to toxic chemicals, chemotherapy drugs, excessive alcohol consumption, lack of essential vitamins, autoimmune diseases, drug reactions, bacterial infections in the blood, pregnancy can cause low blood platelets

doi:10.1093/ajhp/72.14.1239 125Peters P, Miller R

For example, long-term use of oral contraceptives may lower levels of Vitamin B2 (riboflavin) , while some diabetes and epilepsy drugs affect Vitamin B12 (cobalamin) levels