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10.1016/j.peptides.2008.12.007 65 KarasawaH.YakabiS.WangL.StengelA.RivierJ.TachY

All individuals with these atypical variants exhibited skin hyperextensibility as seen in individuals with cEDS and clEDS and evidence of tissue fragility as seen in individuals with vEDS demonstrating the importance of gene panel testing

Reducing dose typically resolves symptoms while still providing benefits

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