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4-HNE is involved in PD pathology by covalently modifying -syn to promote its aggregation, disrupting the ubiquitin-proteasome system, and interfering with dopamine receptor function, and has been found to alter dopamine transport, contributing to dopamine loss (82, 86, 88)

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MTL-CEBPA, a small activating RNA therapeutic upregulating C/EBP-alpha, in patients with advanced liver cancer: a first-in-human, multicenter, open-label, phase I trial