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However, paclitaxel-induced mechanical hypersensitivity is due to central (spinal) oxidative stress maintaining central sensitization and abnormally processing Ab fiber inputs as nociceptive [26]

The same conclusion can be applied to results of the Lab-on the Chip Agilent method (Figure 2b) (Table 4) where it is evident that LP4 and LP24 for example, show clear bands after magnetic beads isolation of about 150KDa, while Melon Gel purified antibody bands are followed by several bands of lower molecular weight indicating impurities in the final product of purification

Glutamate binding onto iGluRs opens cation channels, depolarizing the postsynaptic cell membrane

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