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doi: 10.3171/2014.9.FOCUS14496 38 BarresiVSimboloMMafficiniAPireddaMLCaffoMCardaliSMet al

In toxin-induced PD models (e.g., MPTP or MPP + ), these inhibitors protect dopaminergic neurons by suppressing iron-mediated ROS formation, reducing lipid peroxidation, and restoring mitochondrial and synaptic integrity (271, 272)

The sarco/ER Ca 2+ -ATPase (SERCA) channels mediate calcium uptake into the ER to restore the cytoplasm-ER calcium gradient and terminate calcium flux-mediated signaling