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Under normal conditions NAPQI is metabolised by conjugation with glutathione to form cysteine and mercapturic acid conjugates

One of which is the stability and bioavailability of orally administered NAD + precursors, which induce slow and suboptimal NAD + increases 39,69

Although high doses of APAP are well known to be associated with increased risk of liver failure, chronic exposure to standard therapeutic doses is also not without risk

Identification of potential functional DEGs in glutathione metabolism To understand the gene interaction within glutathione metabolism, we constructed the gene network using the MCODE app of Cytoscape software