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Analyst 141 , 31263140, (2016)

In -syn transgenic mice, sustained physical activity increases PPAR and TFEB expression/nuclear localization and upregulates LAMP2 and CTSD, whichtogether with macroautophagy and chaperone-mediated autophagy (CMA)promote -syn clearance (Sala et al., 2016)

In fact, a study looking at the Pfcrt changes over a 13 year period between 1993 and 2006 in Kilifi, Kenya found that the 76T mutation only decreased from 94% to 63% [38]