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Nevertheless, many currently ongoing clinical trials are focused on inhibition of Pioglitazone, an agonist of peroxisome-proliferator-activated receptor gamma (PPAR), acts on astrocytes and regulates metabolic coupling of astrocytes/neurons (Cowley et al., 2012), promotes the formation of dendritic spines and synapses (Moosecker et al., 2019), ameliorates amyloid and tau pathology in animal models (Singh, 2022), and improve learning and memory (Cowley et al., 2012)

During follow-up 29.4% on bisphosphonates, 6.3% on denosumab and 0.8% on raloxifene.42.9% of the patients who experienced a new Fx were treated with bisphosphonates, 7.1% with denosumab

One safety note: topical Retinoids aren't recommended during pregnancy or breastfeeding

Molecular genetic analysis in mild hyperhomocysteinemia: a common mutation in the methylenetetrahydrofolate reductase gene is a genetic risk factor for cardiovascular disease