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3 Using mouse embryonic fibroblasts with an inducible Gpx4 disruption, we were able to demonstrate that a non-apoptotic form of cell death is elicited upon Gpx4 deletion and that this cell death is preceded by lipid oxidation

Rare driver mutations in head and neck squamous cell carcinomas converge on NOTCH signaling

Its amphipathic nature enables it to penetrate microbial membranes, leading to disruption and subsequent cell death (Zaiou, 2007)