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Currently, multiple means including drug delivery, optimized biodistribution and pharmacokinetics have been put forward to enhance the precision of therapies

Psychoneuroendocrinology (2011) 36:25865.10.1016/j.psyneuen.2010.07.016 174 KamaliMSaundersEFProssinARBruckschCBHarringtonGJLangeneckerSAet alAssociations between suicide attempts and elevated bedtime salivary cortisol levels in bipolar disorder

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The results revealed a mixture of Cd species with tetrahedral coordination suggesting the formation of [Cd(Cys) 1/2 ] +1 complexes which may represent the nephrotoxic species that are then uptaken by the kidneys (Figure 2) to induce cellular damage by processes that are still incompletely understood (Thevenod and Lee, 2024)