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doi: 10.7554/eLife.07370 23 CaputoG

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For example, TGF-s, bone morphometric proteins (BMPs) and their related peptides, such as P24 and P20, mediate the differentiation of osteoblasts and chondrocyte lineages via both Smad-dependent and Smad-independent signaling pathways, but they recruit distinct receptor heterotetramers and R-Smad complexes, thus exerting different biological effects on osteogenesis, osteoclastogenesis, and chondrogenesis [167]