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To address these gaps, we now emphasize the need for future RCTs to implement more rigorous participant stratification by baseline vitamin K status, sex, age, and disease risk profile, and to utilize higher-dose and longer-duration interventions with menaquinones, particularly MK-7, which demonstrate superior bioavailability and extrahepatic tissue targeting ( 54 )

B.ZhangX.et al (2018)

The potential mechanisms such as enhanced tissue repair, angiogenesis, and anti-inflammatory effects certainly warrant further exploration in human medicine

Severe gastroparesis or significant gastric motility disorders constitute another important contraindication