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Isolated monocytes from CF patients also exhibited increased NLRP3 inflammasome activity following stimulation with LPS (105)

Conversely, it should be noted that some studies suggest that very high levels of NO, such as those produced by NO donors or potentially iNOS, may actually negatively regulate Th1 differentiation required for anti-tumor immunity by leading to the S-nitrosylation of key post-transcriptional regulators of Th1 cytokines and transcription factors (8890)

Representative human LRRC25 cDNA and human LRRC25 protein sequences are well known in the art and are publicly available from the National Center for Biotechnology Information (NCBI) (see, e.g., NCBI

Buzzaccarini G, Marin L, Noventa M, et al