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Heavy smoker (more than 20 cigarettes per day): Step 1 21mg patch per day for 3-4 weeks Step 2 14mg patch per day for 3-4 weeks Step 3 7mg patch per day for 3-4 weeks Moderate/light smoker (less than 20 cigarettes per day): Step 2 14mg patch per day for 3-4 weeks Step 3 7mg patch per day for 3-4 weeks How to use Nicotinell Patches

This, along with the potential secretion of bacterial enzymes such as hyaluronidases and proteases, leads to the breakdown of the epithelial barrier, which in turn facilitates microbial translocation, sustained immune activation, and deeper tissue invasion ( S