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It has been known since the 1970s that, as celebrated tobacco control researcher Michael Russell once described, people smoke for the nicotine but die from the tar. People who use nicotine self-titrate, meaning that they will use a product until they reach the level of blood-nicotine that they are happy with

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Cancer-causing chemicals called tobacco-specific nitrosamines (TSNAs) are formed during the curing process of tobacco leaves