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published in Hormone Research, oral AOD-9604 given to obese Zucker rats for 19 days reduced body weight gain by more than 50% compared to controls, with no adverse effect on insulin sensitivity confirmed by euglycemic clamp testing

NNMT activity tends to increase in fat tissue (white adipose tissue) as people age or gain weight

The investigators reported that NNMT knockdown produced protection from diet-induced obesity and increased adipocyte energy expenditure, establishing the genetic precedent for the 5-Amino-1MQ pharmacological program

While not a substitute for medical evaluation, this data can inform decisions about continued use