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NNK treatment significantly increases macrophage infiltration and expression of pro-inflammatory mediators such as macrophage inflammatory protein 1 alpha (MIP-1, interleukin 1 beta (IL-1), and TGF- in mice neoplastic lesions (117)

[40] It failed to chart outside of Japan, [41] which Sykes once again attributed to Geffen Records, who he felt "didn't do anything" to promote the record