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Additionally, physical challenges like arthritis can make the manual dexterity required for thorough brushing and flossing more difficult

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However, when the effect of oxidation is greater than the antioxidant effect, the infiltration of inflammatory cells occurs, the secretion of various proteases and cytokines increases, and a large amount of oxidative intermediate products are generated, which in turn cause a series of physiological and pathological changes ( free radicals, and excessive O accumulation induces endothelial cell dysfunction through multiple pathways

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