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Nevertheless, silencing of the NtHMA and/or NtHMA gene(s) also changed plant development and impaired seed germination due to Zn deficiency, indicating significantly changed metal homeostasis probably due to pleiotropic effects (Hermand et al

The mechanism behind the reduced birth weight in the exposed group may be the negative effects of nicotine on the development of the placenta and its function leading to decreased oxygen delivery to the fetus [12, 35]

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