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It has long been known that smoking cigarettes which can increase the buildup of plaque in blood vessels, make your blood more likely to clot, block blood flow to the heart and brain, among other cardiovascular effects is a major cause of heart disease and stroke

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Future investigations should integrate longitudinal human cohorts with mechanistic animal studies colonized by smoker-derived microbiota, which may provide causal insight into how specific taxa or metabolites mediate disease trajectories