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[4] Tobacco use leads most commonly to diseases affecting the heart and lungs, with smoking being a major risk factor for heart attacks, [5] [6] strokes, [7] chronic obstructive pulmonary disease (COPD), [8] idiopathic pulmonary fibrosis (IPF), [9] emphysema, [8] and various types and subtypes of cancers [10] (particularly lung cancer, cancers of the oropharynx, [11] larynx, [11] and mouth, [11] esophageal and pancreatic cancer)

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