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Cyclophosphamide and ifosfamide, on the other hand, possess no intrinsic alkylating activity and must be metabolized to produce alkylating compounds

Thus, cysteine conjugates with more nucleophilic sulfur atoms ( S -allyl-L-cysteine, S -benzyl-L-cysteine) were much better microsomal flavin monooxygenase substrates in human kidney and liver and in rabbit liver than were those with less nucleophilic sulfur atoms (the various haloalkyl cysteine and mercapturic acid conjugates) (Ripp et al