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Siegel considers himself firmly in the anti-smoking camp, having testified against tobacco companies about 13 times in his career

Its original vision statement was to enhance natural tobacco components that may have potential to either reduce or mitigate the biological activity of tobacco-burning cigarettes.43 This statement was later amended as follows: to provide smokers with products which contain biological activity mitigants.42 Biological activities targeted included reducing nitrosamine levels, nitric oxide levels, carbonyl groups, Ames activity (a measure of mutagenic and carcinogenic potential), ciliostatic and cytotoxic response, and possibly free radical concentrations.44 Numerous RJ Reynolds documents showed that the company considered adding mitigants, such as beta-carotene, to cigarettes.42 , 47 56 Mitigants were defined as antioxidants and other compounds for free radical reduction (i.e., reduction of the concentration of free radicals)57 , 58

Ananya Mandal is a doctor by profession, lecturer by vocation and a medical writer by passion

Influence of the e-cigarette emission profile by the ratio of glycerol to propylene glycol in e-liquid composition