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In summary, our study supports that MeCbl, a widely prescribed drug, is promisingly repurposed to be an effective therapeutic option to GSDME dependent liver failure, which is characterized with high morbidity and high mortality without efficient clinical therapies

Although little is known about the mechanism of LDR exposure, many studies reported DNA damages, oxidative stress, and pro-inflammatory responses as major mediating events induced by an LDR exposure

Nod factor is structurally similar to fungal cell wall chitin, which is a known activator of the plant immune response (Pusztahelyi, 2018)

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