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Australian researchers estimated that tobacco control interventions should avert about two-thirds of lung cancer deaths that would have been expected by the end of the century in an alternate scenario of no tobacco control inititaives

Tobacco and respiratory diseases Smokers are at increased risk of ENT and lung diseases such as chronic bronchitis and COPD

Farokhnia M, McDiarmid GR, Newmeyer MN, Munjal V, Abulseoud OA, Huestis MA, Leggio L (2020) Effects of oral, smoked, and vaporized cannabis on endocrine pathways related to appetite and metabolism: a randomized, double-blind, placebo-controlled, human laboratory study

The brain still gets its "the meal is complete" signal, just attached to something else