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Recently another group of researchers collected nasal lavage and scrape-biopsy epithelium samples from 14 smokers, 13 nonsmokers, and 12 e-cig users, analyzing RNA with the nCounter Human Immunology v2 Expression panel (assessing 597 immunology-related genes)

Smoking largely kills you via chronic diseases that take decades to build up

However, exposure to cigarette smoke has no bearing on TKI sensitivity of NSCLC cells harboring EGFR activating mutations [36], implying that dysregulation of genes or pathways particularly affected by CSE in EGFR WT cells may explain the distinct impact of CSE on TKI sensitivity

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