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While nicotine itself is not a carcinogen, malignant diseases and neurodegeneration are suspected to result from nicotine.14 A legitimate concern among the children is that if children (non-smokers) develops a nicotine addiction, they may start smoking cigarettes.18 A recent study has suggested that young adults who use e-cigarettes had higher odds of conventional smoking initiation.19 Furthermore, a report published by the National Academies of Sciences, Engineering, and Medicine15 had found evidence of an increase in the risk of tobacco smoking due to e-cigarette use among young adults.15 Hence, these trends pose major public health challenge that requires strict regulation pertaining to access of e-cigarettes

Functional predictions showed disrupted microbial pathways, including amino acid transport and DNA repair, in smokers

with significantly higher rates compared to the U.S

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