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Can I Smoke Cigarettes While on Antidepressants? Key Facts Quitting smoking can help improve your mental health and mood. Smoking can make you feel good at first, but it can often leave you feeling on edge and restless. Nicotine can impact Wellbutrin XL for Depression & Quitting Smoking: Does It Really Work? Smoking and antidepressants pharmacokinetics: a systematic review Annals of General Psychiatry Springer Nature Link
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